Antioxidant Effects of Gamma-oryzanol on Prostate Cancer Cells

Gamma-oryzanol is the major component, 2%, in the extract from rice bran. Rice bran oil contains a mixture of several phytosteryl ferulates. Several reports mention the rice bran oil health beneficial activities, reduction of plasma cholesterol, inhibition of platelet aggregation, and particular antioxidant functions. In Japanese traditional medicine, rice bran oil has been used to ameliorate the effects of menopause, to accelerate growth, to enhance skin capillary circulation, and to treat gastrointestinal problems. Potent antioxidant activity was frequently reported for the radioprotective effect, cancer and chemotherapy (Ismail et al., 2010; Valantina et al., 2010). To date, many scientific papers reported the benefit of gamma-oryzanol and rice bran oil in treating dyslipidemia through its antioxidant activity. The daily consumption of rice bran oil modified milk significantly decreases total serum cholesterol concentrations and tends to decrease cholesterol associated to low density lipoprotein in type 2